IFI6 and neoplasm: Within the lymphoid context, primary tumors exhibited a higher proportion of pro-inflammatory T-cell subtypes, while metastatic samples displayed mixed deregulation of T-cell subtypes, including significant increases in exhausted T cells, IFI6 T cells, naive T cells, MKI67+ T cells, and Tregs, suggesting a shift towards a chronic immunosuppressive tumor microenvironment.