We found that the associations between E/I imbalance and AD proteinopathy remained similar in these models (Supplementary Fig. S1A–D; Aβ-PET: excitability, F = 5.03, P = 0.030; fragility, F = 7.18, P = 0.011; tau-PET: excitability, F = 41.70, P < 0.0001; fragility, F = 2.38, P = 0.136) while there were no significant interactions of CDR with neural excitability or with neural fragility (Supplementary Fig. S1A–D). Here, MAPT is linked to Alzheimer disease.