TNS1 and hepatocellular carcinoma: Our finding that GFAT1-mediated O-GlcNAcylation of VEZF1-Ser123 and VEZF1-Ser124 plays a pivotal role in transcriptional activation of TNS1, suggesting that therapeutic potential for HCC may be conferred by targeting the GFAT1-VEZF1-TNS1 signaling axis through inhibition of this specific modification.