G3BP1 and central nervous system cancer: To investigate SGs in response to chemotherapy drugs, multiple drugs such as cisplatin, doxorubicin, etoposide, or methotrexate were exploited in different cancer cells using the SG markers G3BP1 and TIAR.12,27 Indeed, all the tested drugs induce SG assembly in OS, glioma and NSCLC cells (Figs. 1a, b, and S1).