MYC and neoplasm: Studies have uncovered nucleoli as a stress sensor and signaling hub when cells encounter various stress conditions, such as nutrient deprivation, DNA damage, and oxidative and thermal stress.9 Nucleolar accumulation of mRNAs such as c-myc has been observed in tumor cells.42 tG3BP1-C-mediated nucleolar accumulation of mRNAs of ribosomal proteins may be a new strategy for tumor cells to manage stresses by delivering stress signals from SGs to the nucleus.