G3BP1 and malignant glioma: In summary, our findings reveal a previously unappreciated role of AEP and G3BP1 as modulators of the communication between SGs and nucleoli/mitochondria, provide profound insight into organelle crosstalk under stress conditions, and highlight the therapeutic potential of targeting AEP or SGs to reinforce the efficacy of chemotherapy for refractory tumors, especially OS and malignant glioma.