In this study, chemotherapeutic drug-activated AEP specifically cleaved G3BP1 at N258/N309, producing tG3BP1-Ns, which modulated SG dynamics; moreover, tG3BP1-Cs sequestered mRNAs of ribosomal proteins in the nucleolus to repress translation in OS as well as malignant glioma. The gene discussed is LGMN; the disease is malignant glioma.