G3BP1 and cancer: As G3BP1 is a key protein in SG formation, its regulation carries particular importance.12 For example, G3BP1 ubiquitination mediates SG disassembly in a context-specific manner.13 Translational repression of G3BP in cancer suppresses SG formation and increases stress tolerance.14 Caspase-8 mediated cleavage of G3BP1 subverts SG to promote viral replication.15 Although G3BP1 is associated with chemotherapy,6 its precise function and regulation remain elusive.