The dual role of respiratory commensals in activating innate immune responses while concurrently regulating lung inflammation through IL-10 was also observed with Prevotella, which promotes neutrophil activation and mitigates the harmful effects of inflammation through IL-10 regulation when coinfected with S. pneumoniae in mice.15 Moreover, the highly activated proinflammatory genes and pathways decreased to levels comparable to those in mice without SOR pre-intervention, with no significant difference between the two groups by day 6 post‒infection, when the mice began to recover weight. Here, IL10 is linked to infection.