ACSS2 and head and neck squamous cell carcinoma: To investigate the mechanism by which ACSS2 interferes with lysosomal function in HNSCC cells, we proteomically compared the differential proteins of SCC9 and Cal27 cells with and without ACSS2 knockout, and found that shACSS2 led to a significant decrease in TFEB mRNA level(Fig. S3A, B).