COPZ1 and glioblastoma: These interconnected pathways—involving iron metabolism (TRIM7, COPZ1, IRP-IRE), antioxidant defenses (NF-κB, Nrf2, APOC1), and lipid peroxidation regulation (ACSL4, PRRX2/GCH1/BH4)—collectively determine ferroptosis susceptibility in GBM.