These interconnected pathways—involving iron metabolism (TRIM7, COPZ1, IRP-IRE), antioxidant defenses (NF-κB, Nrf2, APOC1), and lipid peroxidation regulation (ACSL4, PRRX2/GCH1/BH4)—collectively determine ferroptosis susceptibility in GBM. The gene discussed is NFKB1; the disease is glioblastoma.