When considering the hu-CD34+in vivo data in the context of the human Ewing sarcoma data presented in Fig. 1 (demonstrating an abundance of immunosuppressive TGFβ in the Ewing sarcoma TME), we next sought to determine the impact of TGFβ inhibition on the Ewing sarcoma TME following radiotherapy. Here, TGFB1 is linked to Ewing sarcoma.