Altogether, OXT circuits serve as a key regulator for socio-emotional behaviour; MeA-OXT projection facilitates social investigation and anxiety-like behaviour, while BnST-OXT projection conversely attenuates these behaviours; hence a defect of the OXTPVN→BnST circuits contributes to the development of ASD-like social phenotypes in BTBR mice. The gene discussed is OXT; the disease is Anxiety.