Importantly, SMACm have been shown to facilitate death induction in the presence of other cell death ligands, e.g., interferons and TNF-related apoptosis inducing ligand (TRAIL),52 while BET-degrading compounds were previously shown to upregulate TRAIL receptor 2 (TRAILR2) and thereby induce cell death in CRC cell lines.53 Here, TNFSF10 is linked to colorectal carcinoma.