As shown in Figures 1B, 1C, 1D, 1E, 1F,compared with those in the Control Group, the levels of MDA, 8-OHdG, PCD, IL-6and TNF-α in the hippocampi of the mice in the obesity group weresignificantly greater (p < 0.05). This evidence concerns the gene TNF and obesity due to melanocortin 4 receptor deficiency.