Similar to the Western blotting results shown in Figure 5, C and D, quantitative PCR (qPCR) analysis revealed a significant decrease in the mRNA level of NMDARs in Sh2d5-KO mice with epilepsy (Figure 6C), suggesting that SH2D5 may modulate the transcription of NMDARs. This evidence concerns the gene SH2D5 and epilepsy.