In contrast with early CD4+ T cell depletion combined with the E743–77-pulsed bm12 mBMDC vaccine, early Treg depletion did not hamper bm12 mBMDC efficacy at the earlier stages of tumor growth, and tumor growth was delayed until 17 days after TC-1 inoculation, but gradually the tumors grew at a similar rate as those in the mice that received vaccination alone (Figure 6, B and C). This evidence concerns the gene CD4 and neoplasm.