There was a marked significant difference between the bm12 DC vaccine alone and the PBS group (P < 0.0001) and the bm12 DC vaccine combined with late CD4+ T cell depletion and the PBS group (P < 0.0001) over the entirety of the tumor growth before the mice in the PBS group succumbed (on day 25 after TC-1 inoculation). The gene discussed is CD4; the disease is neoplasm.