CD4 and neoplasm: To explore the mechanism of the MHC class II semiallogeneic mBMDCs in vitro, we measured IFN-γ–expressing CD8+ or CD4+ T cells from TC-1 tumor–bearing mice in cocultures of isolated splenic CD8+ T cells or CD4+ T cells stimulated for 24 hours with either WT or bm12 mBMDCs with or without E743–77 pulsing (Figure 3, A and B).