CD4 and neoplasm: Tumor-infiltrating E7/H2Db tetramer+CD8+ T cells were significantly higher in the groups that received the E743–77-pulsed bm12 mBMDC vaccine alone and in combination with late Treg depletion, but only the combination of vaccine with late Treg depletion significantly increased circulating E7/H2Db tetramer+CD8+ T cells in the blood (Figure 6, D and E), showing comparable results with those of the combination of the E743–77-pulsed bm12 mBMDC vaccine and late CD4+ T cell depletion in blood 29 days after TC-1 inoculation (Figure 5J and Figure 6E).