The CCR2 ligand CCL-2 is expressed in calcified aortic valves and increased by inflammatory stimuli.7 During CAVD progression, there is an increased macrophage number in human valves.8 We propose that the higher monocyte CCR2 expression facilitates monocyte recruitment to the aortic valve and contributes to valvular inflammation. This evidence concerns the gene CCR2 and congenital bilateral aplasia of vas deferens from CFTR mutation.