Evidence from 2007 indicated that AKT1 deletion exacerbates atherosclerosis and occlusive CAD, as genetic ablation of AKT1 on an apolipoprotein E knockout background (ApoE(-/-)AKT1(-/-)) led to increased aortic lesion expansion and coronary atherosclerosis [59]. This evidence concerns the gene AKT1 and coronary atherosclerosis.