Building off of prior studies showing that a variety of systemically administered, anorexigenic gut-secreted hormones rapidly inhibit AgRP neurons (7, 8), and that stimulation of AgRP neurons can overcome gut hormone–induced anorexia (43), we showed that fast-acting GLP-1 and GIP analogs rapidly inhibit AgRP neurons (Figure 3). This evidence concerns the gene GLP1R and Anorexia.