CTBP1 and ocular hypertension: Among them, 14 induced remarkable intraocular pressure (IOP) loweringin an in vivo transient model of ocular hypertension,with the maximal effect at 120 min post-administration at 1% w/v concentration.Furthermore, the high stability of the compounds in rabbit plasmaand their ability to induce full vasodilation in isolated porcineretinal arteries suggested that the observed in vivo effects likely result from a combination of conventional aqueoushumor reduction and modulation of ocular vascular tone, both of whichare mediated by CAs and β-ARs.