SP140L and infection: Since Wp is the first promoter activated after infection [57], its higher production of EBNA-LP suggests that EBNA-LP protein production is more important in the early stages of infection, fitting both EBNA-LP’s early detection after B cell infection (alongside EBNA2) [58, 59], and its importance for transcription of other viral genes [3], likely by preventing Sp100 and Sp140L from repressing un-transcribed regions of the EBV genome [4].