GLI1 and craniosynostosis: GLI transcription factors emerge as critical nodal points, where mutations trigger severe developmental defects [25, 70, 130], GLI3 dysfunction causes craniosynostosis and calvarial hyperossification [152], while GLI2/GLI1 perturbations underlie syndromic conditions like Pallister‐Hall and Greig cephalopolysyndactyly [61, 151, 167, 168, 169, 170].