INS and cancer: Importantly, the KEGG pathway analysis highlighted the involvement of DMGs in key signaling pathways, such as Type ll diabetes mellitus, signaling pathways regulating pluripotency of stem cells, Regulation of lipolysis in adipocytes, ras signaling pathway, Rap1 signaling pathway, proteoglycans in cancer, pathways in cancer, lysine degradation, insulin signaling pathway, and insulin resistance (Fig. 4D).