However, in rat neural stem cells, Hspa4 is upregulated by selegiline, a type B monoamine oxidase inhibitor used to treat PD, and Hspa4 upregulation reduces ROS levels and mitochondrial DNA damage following hydrogen peroxide exposure (Abdanipour et al., 2018; Elkenani et al., 2022). The gene discussed is HSPA4; the disease is Parkinson disease.