When SCN9A-related phenotypes were evaluated, it was determined that the loss-of-function mutation in SCN9A explained the insensitivity of the SDS patient to pain but not the bone marrow failure, pancreatic insufficiency, or neurological abnormalities [Online Mendelian Inheritance in Man (OMIM) 243000 and RRID:SCR_006437). This evidence concerns the gene SCN9A and exocrine pancreatic insufficiency.