However, during inflammatory conditions, abundant in pro‐inflammatory cytokines such as IL‐6 as observed during periodontitis and PI (Rojas et al. 2021; Tsukasaki et al. 2018; Chen et al. 2019), Tregs can lose their typical regulatory phenotype and acquire a pro‐inflammatory and osteolytic profile, instead. This evidence concerns the gene IL6 and periodontitis.