When compared to CPP-granzyme-B conjugates and free granzyme-B, TAT-granzyme-B-PMPC/HA NCs had the highest tumor accumulation and cellular uptake, resulting in the most tumor reduction.66 NCs designed for intracellular delivery of d-amino peptides via a poly-arginine-derived CPP motif also enhanced cellular uptake via clathrin-mediated endocytosis and showed improved accumulation and uptake in non-small cell lung cancer.67 Here, GZMB is linked to neoplasm.