The results showed that treating mouse peritoneal macrophages with VEGF‐B or Gremlin‐1 alone could also inhibit the production of inflammatory factors (Figure 8G,H), indicating that hepatic GSDMD might release inflammatory inhibitory factors including VEGF‐B and Gremlin‐1 through pore‐forming activity to inhibit the production of inflammatory factors from macrophages, thereby alleviating the inflammatory response of mice with LPS‐induced sepsis. Here, VEGFB is linked to Sepsis.