To further validate our results, we repeated the above experiments in the cecal ligation and puncture (CLP)‐induced sepsis model, which closely resembles the progression and characteristics of human sepsis.[15] The results showed that liver‐specific knockout of GSDMD significantly aggravated the inflammatory response and lung injury in CLP‐induced sepsis, which was consistent with the results of the LPS‐induced sepsis model (Figure 3). This evidence concerns the gene GSDMD and Sepsis.