GSDMD and Sepsis: At the same time, compared with the mice injected with GSDMD‐c.D276A, which could not play a pore‐forming role, the levels of inflammatory factors in serum and peritoneal perfusion and the number of peritoneal macrophages in mice replenished with full‐length GSDMD were also significantly lower (Figure 7C,D), indicating that hepatocyte‐specific replenishment of full‐length GSDMD could effectively alleviate the inflammation response in mice with LPS‐induced sepsis.