Later, we performed serum proteomic analysis on the serum of mice in the LPS‐induced sepsis models of GSDMDflox+/+ mice and GSDMDhep‐/− mice and found that the levels of anti‐inflammatory factors (Gas6, Activin A, TRANCE, Fas, sFRP3, Gremlin‐1, TWEAK, VEGF‐B, etc.)in the serum of GSDMDhep‐/− mice were significantly reduced (Figure4A). The gene discussed is FRZB; the disease is Sepsis.