In addition to the upregulation of typical fibrosis-associated genes (Col1a1, Fn1 and Acta2), an increase in Prrx1a and Prrx1b mRNA expression was previously reported during fibrosis development in the bleomycin model of lung fibrosis (Marchal-Duval et al., 2023). The gene discussed is ACTA2; the disease is pulmonary fibrosis.