Recently, lineage tracing using a Prrx1:CreERT2 mouse line demonstrated that a Prrx1-positive mesenchymal cell population – referred to as the Prrx1enh subpopulation – was amplified and associated with fibrosis development after skin injury in the mouse ventral dermis (Currie et al., 2019; Leavitt et al., 2020), and it modulated skin inflammation during atopic dermatitis (Ko et al., 2022). Here, PRRX1 is linked to fibrosis.