PRRX1 and familial pancreatic carcinoma: Additionally, in a pancreatic cancer mouse model, Prrx1 conditional loss of function in cancer-associated fibroblasts, using a different Prrx1fl allele and the Sm22-CreERT driver mouse line, resulted in increased extracellular matrix deposition and the accumulation of myofibroblasts (Lee et al., 2022).