Cognitive impairment has been reported in ALS/FTD (Rusina et al., 2021), and cognitive impairment detected by the Edinburgh Cognitive and Behavioural ALS screen has been found to be a valid predictor of TDP-43 pathology in patients with ALS who do not have clinical dementia (Gregory et al., 2020). The gene discussed is TARDBP; the disease is Cognitive impairment.