In addition to the above‐mentioned enzymes, MMP‐3 and MMP‐13 are involved in the pathogenesis of tendinopathy being associated with excessive ECM turnover, which leads to structural and functional alterations.[57, 58] The upregulation of MMP‐13 contributes to the transition from acute tendon injury to chronic tendinopathy by perpetuating collagen degradation and interfering with tissue repair processes. This evidence concerns the gene MMP13 and disease of the tendon.