The results unveiled that compared with the control group, plasma FAP activity (164.29 ± 66.67 RFU/min vs. 107.83 ± 53.01 RFU/min) and level (175.60 ± 109.82 ng/ml vs. 95.37 ± 68.17 ng/ml) were significantly higher in the T2DM with HFpEF group (Figure 1a and b). This evidence concerns the gene FAP and type 2 diabetes mellitus.