FAP and type 2 diabetes mellitus: However, the E/A ratio, an indicator reflecting HFpEF [21], was significantly decreased in the WT T2DM-induced HFpEF group and improved following FAP KO in the T2DM-induced HFpEF model (Figure 3b), signaling that FAP KO assisted in mitigating cardiac dysfunction in mice with T2DM-induced HFpEF.