The V337M mutant interactome reveals the exclusive presence of CRL4‐CRBN E3 ubiquitin ligase family complexes (CPX‐2759, CPX‐2762) regulating a broad spectrum of biological processes, encompassing ion channel regulation, cancer development, immune regulation and energy metabolism regulation, which can be correlated well with the enriched pathways for the V337 Tau‐F specific interactome. The gene discussed is IL17RB; the disease is cancer.