Consistent with the functional restoration observed in MM patient samples ex vivo (Figure 4E,F), NK1.1 blockade significantly boosted in vivo production of Tnf, Ifng, Gzmb, and Il2 in mice, but this enhancement was substantially attenuated when NK1.1 blockade was combined with CD8+ T‐cell depletion (Figure 5F). This evidence concerns the gene TNF and Miyoshi myopathy.