In addition to MM, our findings reveal a KLRB1‐driven exhaustion program in CD8+ TRM across various hematologic malignancies, a pattern also observed in solid tumors.[8, 9, 12] Notably, in Human Papillomavirus (HPV)‐positive oropharyngeal squamous cell carcinoma, elevated CD161 expression on CD8+ TRM correlates with reduced antitumor activity, further supporting the relevance of TRM‐specific exhaustion mechanisms across tumor types.[12b] Moreover, high CD161 expression has been reported to be associated with poor outcomes in several malignancies. Here, KLRB1 is linked to neoplasm.