For example, pathogenic MYH7 variants have been linked to a higher incidence of new-onset AF in patients with HCM, with a hazard ratio of 1.72 (95% confidence interval, 1.27–2.33) compared to MYBPC3 variants, based on data from the multinational registry of 1,040 genotype-positive, AF-free adult HCM patients followed for a mean of 7.2 years [54]. The gene discussed is MYBPC3; the disease is atrial fibrillation.