The DUX4 ORF was later found to be evolutionarily conserved by the Hewitt group, prompting the statement in 2007 that “Together with the conservation of the DUX4 ORF for > 100 million years, this strongly supports a coding function for D4Z4 and necessitates re-examination of current models of the FSHD disease mechanism” [111]. The gene discussed is DUX4; the disease is facioscapulohumeral muscular dystrophy.