Newcomers to the field of FSHD often think that DUX4 history started in 2010 with the key publication of a large multicentre genetic study led by Silvère van der Maarel [23], showing that a permissive allele (4qA) provides a polyadenylation signal (PAS) to stabilize DUX4 mRNA allowing for translation to the muscle-toxic DUX4 protein [23]. The gene discussed is DUX4; the disease is facioscapulohumeral muscular dystrophy.