DUX4 and facioscapulohumeral muscular dystrophy: Overexpression of Pax3 or Pax7 was shown to mitigate the ability of DUX4 to cause death in murine cells [128], leading to the idea that in FSHD, DUX4 also interferes with the capacity of PAX3 and PAX7 to regulate their target genes [128, 132].