Expression of DUX-IGH in B-cells/their precursors in B-ALL is consistent with observations that DUX4 and transcripts of its target genes can also be detected in immortalised B-cell lymphoblastoid clones from FSHD patients, although their immortalisation with Epstein–Barr virus is a confounding factor [229, 230], and DUX4 expression was not detected in primary FSHD peripheral blood cells [231]. The gene discussed is DUX4; the disease is precursor B-cell acute lymphoblastic leukemia.