The results reveal that Yuye Jinhua Qingre Tablets achieves a "anti-inflammatory-repair" synergistic effect by inhibiting the complement cascade, blocking C5a/C5aR1 signal transduction, and regulating the pro-inflammatory phenotype transformation of macrophages, providing a theoretical basis for the molecular mechanisms of Traditional Chinese Medicine in treating acute pharyngitis. The gene discussed is C5AR1; the disease is acute pharyngitis.