First, while SBS1 is a “clock-like” signature [1, 2, 5], dMutSα CRCs were significantly younger than dMutLα cancers (median 57 versus 72 years, P = 1.5 × 10−4; Table 2), indicating that the former's higher CpG > TpG and SBS1 activities were not age-associated. Here, CLOCK is linked to cancer.