To gain deeper insights into the spatial interactions between NECTIN2 and TIGIT, we analyzed two representative tissue samples manually annotated by a board-certified anatomic pathologist: (1) a sample characterized by tumor and fibrosis-dominant regions (PDACP_3) and (2) a sample exhibiting a dense ring of lymphoid cells (PDACP_8) [44]. Here, NECTIN2 is linked to neoplasm.