This also demonstrated that genetic factors capture additional information beyond family history of dementia and that the ADRD PRS adds modest but incremental predictive value beyond APOE4. Adding metabolites predictive of dementia risk to the model further improved the time-specific model performance, indicating that metabolites provide additional predictive value beyond the MedDiet and other major dementia risk factors (average AUC = 0.78; Supplementary Table 22). The gene discussed is APOE; the disease is dementia.