We cultured human lung fibroblasts HFL1, and after co-culturing them with tumor-derived exosomes, we found that HFL1 cells could uptake exosomes (Fig. 3E), and the proliferative and migration capacity of HFL1 was significantly inhibited after treatment with A549-derived or H1299-derived exosomes (Fig. 3F, G). The gene discussed is CFHR1; the disease is neoplasm.