Park et al. [73] reported that “Arylesterase (ARE) and paraoxonase-1 (PON1) activity may be used as markers to predict the response to diet”, suggesting that dietary factors and other epigenetic modifications can have a significant effect on the genomic stability of patients with MetS and the expression of mRNAs and proteins associated with MetS. The gene discussed is PON1; the disease is metabolic syndrome.