INS and hypertensive disorder: Impaired lipid metabolism increases FFA concentrations, activates Toll-like receptors (TLRs) on endothelial and immune cells, and initiates inflammation and oxidative stress, resulting in the loss of insulin-mediated vasodilation, impaired production of reactive oxygen species and subsequent clearance of nitric oxide, and FFA-induced vasoconstriction and exacerbation of hypertension, causing glucose and lipid metabolism disorders and aggravating MetS [68, 69].