MAPK3 and ischemic stroke: At the forefront, strategies targeting neutrophil trafficking have shown considerable promise: CXCR2 antagonism effectively attenuates CNS-directed neutrophil migration during neuroinflammation [160] and ischemic stroke [161], while modulation of the 67LR-ERK1/2-MIP-2 axis through ERK1/2 inhibitors such as U0126 has demonstrated efficacy in reducing neutrophil infiltration in epileptic conditions [132].