Similar A1 responses are observed in various neurodegenerative conditions, including Alzheimer’s disease (AD) [73], Huntington’s disease (HD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), and MS, all of which demonstrate positive immunoreactivity for C3 and other A1-specific markers. The gene discussed is C3; the disease is amyotrophic lateral sclerosis.