The lysosomal score calculated from the three lysosomal stains correlated with gene sets of the senescent secretory phenotype (Fig. 2C), confirming its suitability to detect senescence of neuroblastoma models, although other senescent markers, such as IL-6, are still relatively lowly expressed in neuroblastomas in comparison to senescent low-grade glioma cells (Suppl. This evidence concerns the gene IL6 and glioma.