It has been shown that the increase in glutamine metabolism supports the activation of mTORC1 in the presence of fructose and promotes the expression of downstream inflammatory factors.13,30 Jiang et al. reported that mTOR signaling promotes periodontitis progression by promoting the differentiation of Th1 and Th17 cells.31 To identify the activation of mTORC1 in fructose-treated T cells, T cells were cultured under Th0, Th1, and Th17 cell induction conditions, and western blotting was performed to determine the levels of phospho-mTOR (Ser2448). Here, MTOR is linked to periodontitis.