AKT1 and cancer: Firstly, our analysis revealed a pronounced positive correlation between HuR and various signaling pathways across cancer types, specifically G2M Checkpoint, DNA Repair, PI3K Akt mTOR, MTORC1, Mitotic Spindle, Notch, Hedgehog, and Wnt/β-catenin, which primarily influence tumor cell cycle and proliferation regulation (S6A Fig).