This study presents an in‐depth analysis to verify the impact of cardiorespiratory fitness and central obesity (VAT) on systemic metabolic and inflammatory status, the inflammatory response of whole blood cells and PBMC to in vitro stimulation with two immunogens, the inflammatory and stimulatory phenotype of PBMC, and CD4+ T cells inflammatory response before and after differentiation into Treg cells associated with mTORC1 and mTORC2 inhibition in young adult males and females. This evidence concerns the gene CD4 and Abdominal obesity.