LPA and atherosclerosis: Lipoprotein oxidation fosters foam cell formation and increased arterial lipid burden, and oxidized LDL associates with higher risk of ASCVD events in patients with coronary disease.6 Levels of oxidized Lp(a) predicted CV events in Type 2 diabetes better than non-oxidized Lp(a).7 These observations inspire the hypothesis that therapeutic interventions that reduce the oxidation of Lp(a) limit its atherogenicity independent of changes in concentration.