Our results provided a comprehensive urinary protein profile for people at high risk of Schistosoma haematobium infection, and identified the proteins SYNPO2, LCAT, CD276 antigen, hnRNPM, and α2M as potential diagnostic markers that could improve the sensitivity and specificity of Schistosoma haematobium detection. The gene discussed is A2M; the disease is urinary schistosomiasis.