Changes in GCF PGRN and PGRN/TNF-α molar ratio may be associated with periodontal disease and post-treatment outcomes (ClinicalTrials.gov ID: NCT05535049).<h4>Plain language summary</h4>Progranulin (PGRN) is a protein with complex physiological functions, producing granulin peptides that promote inflammatory and anti-inflammatory activity. This evidence concerns the gene GRN and periodontal disorder.