This research aims to detect the frequency of HMGA2 protein presence in the bladder tissues of Syrian patients with bladder cancer across different tumor stages and grades, with the goal of suggesting its incorporation into the diagnostic approach for bladder cancer, as HMGA2 protein has been highlighted due to its prominent regulatory role in cellular signaling pathways that play a central role in carcinogenesis and tumor progression. This evidence concerns the gene HMGA2 and neoplasm.