[16] In addition, NNMT inhibitors (NNMTi) alone or in combination with 2-deoxy-D-glucose and BPTES have been reported to inhibit cell survival in ccRCC cell lines and primary tumor and metastatic models, suggesting that NNMT inhibitors may provide a new therapeutic strategy for ccRCC and function as a sensitizer for combination therapy [16]. The gene discussed is NNMT; the disease is nonpapillary renal cell carcinoma.