Furthermore, SFTSV infection to HUVECs was significantly inhibited by the treatment with R428 (AXL kinase inhibitor), pictilisib (PI3K inhibitor), U73122 (PLC inhibitor), EIPA (macropinocytosis inhibitor), and BLB (myosin II inhibitor) (Fig. 6F) as seen in HEK293AXL cells, suggesting that SFTSV utilizes AXL for entry to various types of cells through the PI3K- and PLC-dependent micropinocytosis. Here, HSPG2 is linked to infection.