RAC1 and infection: In contrast, treatment with inhibitors of macropinocytosis, including the Rac1 inhibitor NSC23766, the Na+/H+ exchanger inhibitor 5‐(N‐ethyl‐N‐isopropyl) amiloride (EIPA), the non-muscle myosin II inhibitor blebbistatin (BLB), the actin polymerization inhibitor cytochalasin D, significantly curtailed SFTSV infection in HEK293AXL and HEK293AXL-Y799/821A cells but not in HEK293AXL-Y866A (Fig. 5E through H).